Platelets, Thrombosis and Cancer > Laboratory Projects
1. Mechanism procoagulant platelet formation
- Mechanism of thrombin mediated procoagulant platelet formation: PAR and GP1b mediated signalling pathways
- Mitochondrial function and procoagulant platelet formation
- Genetic drivers of procoagulant platelet formation.
- Bruton Tyrosine Kinase pathway in platelet function.
2. Roles of procoagulant platelets in vascular disease and cancer
- Effect of remote ischaemic preconditioning on procoagulant platelet formation (in collaboration with Vascular Biology Group)
- Myeloproliferative disease (in collaboration with Singapore General Hospital)
- Acute coronary syndrome and ischaemic stroke (in collaboration with Platelet function group, Cambridge University, UK)
3. Clot wave analysis: predictors of severity in haemophilia and thrombophilia
4. Aging and platelet reactivity (in collaboration with Vascular Biology Group)
5. Super-resolution imaging of platelet membranes and cytoskeleton
Clinical Research Projects
- ACAT: Anti-coagulation in Cancer Associated Thrombosis
- ENRICH: Sydney Catalyst project biomarkers in lung cancer
International Collaborations
- Professor Willem Ouwehand, University of Cambridge
Platelet Function Team and Thrombogenomics, Department of Haematology, University of Cambridge, UK.
“Procoagulant platelets in acute coronary syndrome and ischaemic stroke.”
Cambridge Platelet Function Cohort: Genomics of platelet function in health and disease. - Professor Lai Heng Lee, Singapore General Hospital
“Procoagulant platelets as predictors of thrombosis in myeloproliferative disease.”
Ongoing exchange of clinical, basic and translational research in myeloproliferative disorders.
National Collaborations
- Australian Red Cross Blood Service
Dr Denese Marks and Dr Lacey Johnston<
“Procoagulant function after agonist stimulation in platelet transfusion products: comparison standard, cold stored and cryopreserved platelet preparations: in vitro and in vivo.”
Platelet Research Group, ARCBS. - ICPMR Haematology, Westmead
Dr Leonardo Pasalic
“Procoagulant platelets in sepsis and bacteraemia” - Australian Centre for Blood Diseases, Melbourne.
Dr. Justin Hamilton, Megakaryocyte and Platelet Biology Group,
Protease receptor pathways in procoagulant platelet formation
